Charge compensation during the phagocyte respiratory burst

Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst.

Granulocytes generate a "respiratory burst" of NADPH oxidase-dependent superoxide anion (O(2)(-*)) production that is required for efficient clearance of bacterial pathogens. Hv1 mediates a voltage-gated H(+) channel activity that is proposed to serve a charge-balancing role in granulocytic phagocytes such as neutrophils and eosinophils. Using mice in which the gene encoding Hv1 is replaced by ...

Identification and quantitation of superoxide anion: essential steps in elucidation of the phagocyte "respiratory burst".

Molecular basis of activation and regulation of the phagocyte respiratory burst.

The molecular basis of activation and regulation of the phagocyte respiratory burst is discussed with particular reference to the role of inositol phospholipid hydrolysis, guanine nucleotide coupling proteins, and activation of protein kinase C.

Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution

Inflammation resolution is an active process, the failure of which causes uncontrolled inflammation which underlies many chronic diseases. Therefore, endogenous pathways that regulate inflammation resolution are fundamental and of wide interest. Here, we demonstrate that phagocyte respiratory burst-induced hypoxia activates macrophage erythropoietin signalling to promote acute inflammation reso...

The effect of exercise with low and high intensity on respiratory burst activities and neutrophils counts

Introduction: Although exercise his effects on human immune system, but its causes is not significantly cleared yet. This study is aimed to investigate the effect of exercise with moderate and high intensity, on changes of respiratory burst activities and neutrophil counts in college judoists. Methods: 10 male college judoists participated in this quazi-experimental study. Subjects run o...